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After azithromycin stock 's announcement, Pfizer plunged $1.80, or 10.3 percent, to $15.65 in New York Stock Exchange composite trading, the most in strattera more than two years. The Wyeth acquisition will ease Pfizer's transition to the post-Lipitor era, increasing annual revenue 47 percent to $70 billion from products including the depression pill Effexor and pneumonia vaccine Prevnar. #x201C;Acquiring enalapril maleate  another slow-growing company turns Pfizer into a solid company that won't grow any better than Pfizer is right now.#x201D;

The Wyeth transaction marks a departure for Kindler, who said in March he didn't see a major acquisition that makes sense, said Tim Anderson, a Shay C. Piotr strattera affiliate Pettypiece in New York at. #x201C;A lot of the flonase turmoil from those acquisitions hurt morale and productivity, no doubt. Creating growth on a revenue base that large #x201C;would seem to be nearly impossible,#x201D; Anderson wrote in a note to investors. McKinnell was CEO for 5 years and 7 months before Kindler succeeded him in July 2006.

He also reorganized scientists into smaller units to decrease bureaucracy and started an independent biotechnology center in California. synthroid fat loss Buying Wyeth also promises Pfizer access to biotechnology products, which aren't susceptible to generic competition.

Finally, he stopped work on more than 100 experimental treatments to focus on a smaller group of diseases. Who contend the company's hormone-replacement prometrium medicines Prempro and Premarin caused their breast cancer.

Lipitor boomed, growing to become the best-selling prescription medicine in the world, with $12.4 billion in sales last year. #x201C;In promethazide  Pfizer's case, because of its size, the new needle will be hard to budge unless many new, big drugs are simultaneously discovered,#x201D; Pembroke wrote. The plan reflects Kindler's failure to offset looming generic competition to Lipitor, Pfizer's best- selling cholesterol pill, using job cuts, new research priorities and sales in developing countries, analysts said.

Wyeth also has a drug in development, micardis hct the Alzheimer's medicine bapineuzumab, that analysts have said may generate more than $8 ethinyl estradiol billion in peak annual sales by 2015.

Celebrex sales, though, were cut almost in half in 2005 after the recall of the similar-acting Vioxx, and Bextra was pulled from the market because of side effects. Adding Wyeth's products will keep Pfizer's annual earnings, after adjustments, at the $2.42 level through 2012, Pfizer said. #x201C;It by no means creates a growth control of sciatica with antibiotics company.#x201D;

As a result of the transaction, Pfizer will cut its quarterly dividend in half, fire 15 percent of the combined company's workforce, or about 19,000 employees, and close five factories. terbinafine cream But we've strengthened the company and culture.#x201D;

Pfizer reported avalide 2008 net income of $1.20 a share, or $2.42 a share after backing out one-time items.

benefited shareholders,#x201D; said Kelby Obuchowski, chief investment officer at First Empire Asset Management of Hauppauge, New York, in an interview. It also may leave the New York-based drugmaker struggling to increase profit past 2012, said Jon Fisher, who manages postinor 1 levonorgestrel $1.5 billion of securities at Fifth Third Asset Management, in Minneapolis. The dividend, which totaled $1.28 a share last year and exceeded the net income of $1.20 a share, is being trimmed to free up cash, Pfizer said in 's statement, without disclosing how much it would save by reducing the dividend.
 * 1) x201C;The string of large acquisitions in the past never


 * 1) x201C;Bigger isn't better.#x201D;

The back-to-back megadeals left Pfizer with excess generic mirtazapine factory capacity, a bloated research operation and too few products in development, investors and analysts said. Pfizer would also gain the rheumatoid-arthritis mupirocin ointment  treatment Enbrel, which Wyeth sells with Amgen Inc. Supreme Court is also considering whether to uphold a $7 million verdict to a woman who lost her arm after being injected with one of the company's vaccines. To contact the reporter on this story.

Pfizer may also inherit Wyeth's legal woes. Wyeth has biotechnology capabilities and a vaccine business that generated $2.4 billion in sales in 2007. That compares with the more than 15 percent drop in adjusted turmeric with synthroid earnings that analysts had expected by 2012, according a survey conducted before the Wyeth plan was announced. indinavir Wyeth is facing claims by more than 10,000 women in the U.S. Wyeth dropped 35 cents, or less than 1 percent, to $43.39.

Pfizer, the world's biggest drugmaker, said it will buy Wyeth, of Madison, New Jersey, for $50.19 a share, or more than $68 billion. Under the plan to buy Wyeth, the combined company's revenue is likely to contract to $62 billion in 2015 antibiotic for gout infection from $73 billion in 2010, said Anderson, the Bernstein analyst. In 2003, after McKinnell took over the top job, Pfizer paid $58 billion for Pharmacia Corp. McKinnell didn't return phone calls left at a number listed for him and generic singulair on telephone-answering machines at two companies for which the executive serves as a director.

Since becoming CEO, Kindler has fired more than 15,000 workers and closed five research centers.

While helping make the company more efficient, none of Kindler's moves reversed the stock's slide. During his two years as CEO, the shares fell 42 percent, a figure that mirrors his predecessor's performance.

acquisitions,#x201D; Kindler said at a news conference in New York. Wyeth also set aside $21 billion to resolve lawsuits from a decade of litigation over its fen-phen diet pill, which was pulled off the market in 1997 after researchers linked the treatment to heart damage and fatal lung disease. And its pain-killing medicines Celebrex and Bextra. Pfizer's Kindler Resorts to a Megadeal infection antibiotic plantronics as Research Falls Flat
 * 1) x201C;We have obviously tetracycline rash learned a lot from our previous

-- Pfizer Inc.'s bid to buy Wyeth revives the megamerger strategy of Chief Executive Officer Jeffrey Kindler's predecessor, Devland McKinnell, whose five-year reign was marked by a 43 percent drop in the company's value.

The acquisition #x201C;is just something that slows the downward spiral,#x201D; Fisher said in a telephone interview. #x201C;As Pfizer proved with the Pharmacia acquisition, just having more money to spend on RD and marketing doesn't make you a more competitive threat, or a better company,#x201D; Fisher, the Fifth Third analyst, said. While being groomed for the chief's job, McKinnell was instrumental in the $120 billion purchase of Warner-Lambert Co., the developer of Lipitor, in Berget 2000.